SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including OmicronSARS-CoV-2 융합 억제 리포펩티드는 오미크론을 포함한 다양한 관심 변종에 대해 높은 효능을 유지합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity Alpha antiviral activity Beta broad-spectrum antiviral broad-spectrum antivirals Cell Cell fusion cell-cell fusion combating COVID-19 pandemic D614G Delta drugs effective vaccine Effective vaccines exhibited FIVE fusion inhibitor Gamma Impact Infection inhibiting inhibitor inhibitors Lambda lipopeptide maintain mutant omicron Omicron variant other variant other variants outbreak pseudovirus pseudovirus pseudovirus infection pseudoviruses reduced S protein S proteins SARS-CoV-2 significantly the S protein therapeutic variant variants variants of concern variants of concern. VoC VOCs wild-type WT virus [DOI] 10.1080/22221751.2022.2098060 PMC 바로가기 [Article Type] Article
Binding and neutralizing abilities of antibodies towards SARS-CoV-2 S2 domainSARS-CoV-2 S2 도메인에 대한 항체의 결합 및 중화 능력Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody B.1.1.7 B.1.351 B.1.617.2 B.1.621 binding binding activity carried conserved convalescent patient coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 determined by domain ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated Evidence Immune escape immune protection mAb mAbs MERS MERS-CoV Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus molecular monoclonal antibodies monoclonal antibody N Terminal N terminal domain NAbs Neutralization assay neutralization assay. Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody NTD P.1 Protein pseudo-virus RBD Receptor binding domain reported Research respiratory Result S protein S proteins S2 protein S2 subunit SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S2 SARS-CoV-2 WT Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly specific antibodies subunit target targets terminal Vaccine design variant variants wild-type [DOI] 10.1080/21645515.2022.2055373 PMC 바로가기 [Article Type] Article
Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기
Fluorescent nanodiamond-based spin-enhanced lateral flow immunoassay for detection of SARS-CoV-2 nucleocapsid protein and spike protein from different variantsArticle Published on 2022-10-162022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] anti-S IgG antibody Antigen antigens B.1.1.529 B.1.1.7 B.1.617.2 binding can be used comparable COVID-19 COVID-19 pandemic current Delta demonstrated Detection limit Diagnosis diagnostic Direct dropped ELISA finding Flow fluorescent Fluorescent nanodiamond incubated Infectious disease Laboratory Lateral lateral flow immunoassay limitations membrane mutations NC membrane nonspecific omicron platform Protein public health Quantitative reporter responsible S proteins SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SELFIA. Spike protein suggested the SARS-CoV-2 turnaround times variant variants viruses was performed wild-type Wuhan-1 [DOI] 10.1016/j.aca.2022.340389 PMC 바로가기
Systematic analysis and comparison of O-glycosylation of five recombinant spike proteins in β-coronavirusesArticle Published on 2022-10-162022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis antiviral drug Biological functions cell entry characterization characterized Coronavirus-2 D614G domains FIVE functional glycosylated help less membrane fusion mutant N-glycosylation O-glycosylation Recombinant spike protein S proteins S1 protein S1 subunit SARS-CoV-2 Sialylation spike Spike protein Spike proteins Vaccine β-coronavirus β-coronavirus β-coronavirus. β-CoV β-CoVs [DOI] 10.1016/j.aca.2022.340394 PMC 바로가기
IgG Against Human Betacoronavirus Spike Proteins Correlates With SARS-CoV-2 Anti-Spike IgG Responses and COVID-19 Disease SeverityArticle Published on 2022-08-262022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome Against anti-S anti-S antibody anti-S2 anti-SARS-CoV-2 antibody Anti-spike antibody Antibody Response bidirectional cohorts common cold common cold human coronaviruses (HCoVs) coronavirus correlated COVID-19 cross-react cross-reactive antibody cross-reactive antibody response decrease disease disease severity domain Effect elicited HKU1 homologous Human human coronavirus IgG IgG antibody immune immune imprinting. Immunoglobulin morbidity and mortality Multiplex assay OC43 Organ failure Protective RaTG13 recognizing response S proteins S1-reactive antibodies SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection sera serum sample severe coronavirus disease Severity of disease significantly increased SOFA spike strain subject with COVID-19 [DOI] 10.1093/infdis/jiac022 PMC 바로가기
Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort인구 기반 코호트에서 SARS-CoV-2 감염 후 뚜렷한 궤적을 가진 이종 체액성 및 세포성 면역 반응Article Published on 2022-08-182022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] analysis anti-N IgG anti-S responses antibody Antibody responses Cellular immune response cellular immunity cellular response characterized clinical factors Cluster analyses Delta detectable develop Diagnosis FIVE heterogeneity humoral humoral and cellular immunity Humoral and cellular responses identify IgA IgG immune Immunity individual infected individuals Infection maintain membrane Neutralizing activity neutralizing antibody omicron Omicron variants Participants population-based cohort required responses S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individual T cell T cell response T cell responses T cells trajectory variant [DOI] 10.1038/s41467-022-32573-w PMC 바로가기 [Article Type] Article
ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variantsChAdOx1 nCoV-19(AZD1222) 또는 nCoV-19-Beta(AZD2816)는 베타 델타 및 오미크론 변종으로부터 시리아 햄스터를 보호합니다.Article Published on 2022-08-082022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] Antibody titer AZD1222 Beta ChAdOx1 ChAdOx1 nCoV-19 clinical trials Delta delta variant Efficacy evaluate the effect full-length hamster hamsters Heterologous include inoculation lung Lungs Neutralizing antibody titer omicron post inoculation PROTECT Protective Protein real-world data reduced reduction in regimen S protein S proteins SARS-CoV-2 sequence sgRNA shown simian adenovirus-vectored vaccine single dose Substitution substitutions symptomatic disease the S protein vaccination Vaccine variant variants variants of concern vectored vaccine Viral virus VOCs Wuhan-1 [DOI] 10.1038/s41467-022-32248-6 PMC 바로가기 [Article Type] Article
CoVM 2: Molecular Biological Data Integration of SARS-CoV-2 Proteins in a Macro-to-Micro MethodCoVM 2: 거시적 방법에서 SARS-CoV-2 단백질의 분자 생물학적 데이터 통합Article Published on 2022-08-022022-09-11 Journal: Biomolecules [Category] SARS, 변종, 치료기술, [키워드] accumulated addition Affect analyzed association B.1.617.2 binding binding affinity binding state Biological calculated causative agent changes in collected COVID-19 COVID-19 pandemic crystal structure crystal structures Data integration Delta docking examined glycoprotein human proteins human receptor human receptors information integration Interaction lack macro molecular Molecular biology Multiple Mutation omicron physical PPI network Protein protein interaction protein structure protein structure docking protein-protein interaction public health receptor protein Research S protein S proteins SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins selected sequence strain Structure structures variant variants Viral protein Viral proteins virus–host interactions virus–host interactions. [DOI] 10.3390/biom12081067 PMC 바로가기 [Article Type] Article
Electrochemical immunosensors using electrodeposited gold nanostructures for detecting the S proteins from SARS-CoV and SARS-CoV-2SARS-CoV 및 SARS-CoV-2에서 S 단백질을 검출하기 위해 전기도금된 금 나노구조를 사용하는 전기화학적 면역센서Article Published on 2022-07-012022-09-11 Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] amperometry Analysis antibody capture carbon carried Complete Device Diagnosis electrode Features gold Gold nanoparticles group immunosensor Ion limit of detection MAA mercaptoacetic acid monolayer point-of-care proof proof of concept Protein protocol reduction S protein S proteins Saliva SAM SARS-CoV SARS-CoV-2 SARS-CoV-2. selectivity sensitivity target protein target proteins the S protein Volume was performed was tested [DOI] 10.1007/s00216-022-03956-1 PMC 바로가기 [Article Type] Article